CLINICAL TRIALS AND OBSERVATIONS Favorable effect of priming with granulocyte colony-stimulating factor in remission induction of acute myeloid leukemia restricted to dose escalation of cytarabine
نویسندگان
چکیده
Thomas Pabst,1 Edo Vellenga,2 Wim van Putten,3 Harry C. Schouten,4 Carlos Graux,5 Marie-Christiane Vekemans,6 Bart Biemond,7 Peter Sonneveld,8 Jakob Passweg,9 Leo Verdonck,10 Marie-Cecile Legdeur,11 Matthias Theobald,12 Emanuel Jacky,13 Mario Bargetzi,14 Johan Maertens,15 Gert Jan Ossenkoppele,16 and Bob Löwenberg,8 for the Dutch-Belgian Hemato-Oncology Cooperative Group (HOVON), the German AML Study Group (AMLSG), and the Swiss Collaborative Group for Clinical Cancer Research (SAKK)
منابع مشابه
CLINICAL OBSERVATIONS, INTERVENTIONS, AND THERAPEUTIC TRIALS Postremission therapy in older patients with de novo acute myeloid leukemia: a randomized trial comparing mitoxantrone and intermediate-dose cytarabine with standard-dose cytarabine
The treatment of older patients with acute myeloid leukemia (AML) remains unsatisfactory, with complete remission (CR) achieved in only approximately 50% and long-term disease-free survival in 10% to 20%. Three hundred eighty-eight patients (60 years of age and older) with newly diagnosed de novo AML were randomly assigned to receive placebo (P) or granulocyte-macrophage colony-stimulating fact...
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The optimal induction for older adults with acute myeloid leukemia (AML) is unknown. Several anthracyclines have been proposed, but the data remain equivocal. Additionally, few prospective trials of priming with hematopoietic growth factors to cycle leukemia cells prior to induction chemotherapy have been conducted. Three hundred and sixtytwo older adults with previously untreated AML were rand...
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In an attempt to improve induction chemotherapy for older patients with acute myeloid leukemia (AML),1314 patients were randomized to 1 of 3 induction treatments for 2 courses of DAT (daunorubicin, cytarabine, and thioguanine) 3 1 10, ADE (daunorubicin, cytarabine, and etoposide) 10 1 3 1 5, or MAC (mitoxantronecytarabine). The remission rate in the DAT arm was significantly better than ADE (62...
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Preclinical models have demonstrated the efficacy of granulocyte-macrophage colony-stimulating factor-secreting cancer immunotherapies (GVAX platform) accompanied by immunotherapy-primed lymphocytes after autologous stem cell transplantation in hematologic malignancies. We conducted a phase 2 study of this combination in adult patients with acute myeloid leukemia. Immunotherapy consisted of aut...
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1Pediatric Hematology and Oncology, University of Frankfurt, Germany; 2Department of Pediatric Hematology and Oncology, Hannover Medical School, Germany; 3Children’s Cancer Research Institute, St Anna Kinderspital and Children’s Cancer Research Institute (CCRI), Vienna, Austria; 42nd Medical School, Charles University, Prague, Czech Republic; 5Department of Pediatric Hematology and Oncology, Un...
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